✦ LIBER ✦

Synthesis and antibacterial activity of novel series of 2-(p-tolyloxy)-3-(5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)quinoline

✍ Scribed by Ratnadeep S. Joshi; Priyanka G. Mandhane; Wajid Khan; Charansingh H. Gill

Publisher: Journal of Heterocyclic Chemistry
Year: 2011
Tongue: English
Weight: 140 KB
Volume: 48
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.653

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✦ Synopsis

Abstract

A new series of 2‐(p‐tolyloxy)‐3‐(5‐(pyridin‐4‐yl)‐1,3,4‐oxadiazol‐2‐yl)quinoline were synthesized from oxidative cyclization of N′‐((2‐(p‐tolyloxy)quinoline‐3‐yl)methylene)isonicotinohydrazide in DMSO/I~2~ at reflux condition for 3–4 h. The structures of the new compounds were confirmed by elemental analyses as well as IR, ^1^H‐NMR, and mass spectral data. All the synthesized compounds were screened for their antibacterial activities against various bacterial strains. Several of these compounds showed potential antibacterial activity. J. Heterocyclic Chem., (2011).

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