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Synthesis and in vitro activity of a non-epimerizable analog of the angiotensin-converting enzyme inhibitor A58365A

โœ Scribed by Derrick L.J Clive; Haikang Yang; Richard Z Lewanczuk


Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
175 KB
Volume
4
Category
Article
ISSN
1387-1609

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Total synthesis of the angiotensin-conve
โœ Francis G. Fang; Samuel J. Danishefsky ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 262 KB

Annulation of the known vinylogous urethane 4 with a-methyleneglutaric anhydride (3) is the key reaction in a seven step enandospecific synthesis of the ACE inhibitor, A58365A (1). The importance of angiotensin-converting enzyme (ACE) inhibitors in the treatment of hypertension has led to widespread