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Synthesis and biological activity of an amino analogue of a tripeptide inhibitor of angiotensin-converting enzyme

✍ Scribed by Ronald G. Almquist; Pamela H. Christie; Wan-Ru Chao; Howard L. Johnson

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
495 KB
Volume
72
Category
Article
ISSN
0022-3549

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Synthesis of the angiotensin converting
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## Abstract We prepared the angiotensin converting enzyme (ACE) inhibitor N‐[1(S)‐carboxy‐3‐(4′‐^3^H)carboxanilidopropyl]‐L‐Ala‐L‐Pro (^3^H‐RAC‐X‐65). The triflate of D‐(+)‐lactic acid benzyl ester was reacted with N′‐(4‐iodophenyl)‐L‐glutamine methyl ester. The benzyl ester was removed with HF, an