In our continuing efforts to elucidate the relationships between the biological activities of iv-acetylmuramoyl-L-alanyl-D-isoglutamine\*\* (MDP) and the structure of the carbohydrate moiety, and to obtain glycopeptide adjuvants that exhibit strong activity and lower toxicity, it was demonstrated th
Synthesis and immunoadjuvant activities of 2-acetamido-5-O-acetyl-6-O-acyl-2-deoxy-3-O-[(R)-2-propionyl-L-alanyl-D-isoglutamine]-D-glucofuranoses as potential prodrug forms of 6-O-acyl derivatives of N-acetylmuramyl dipeptide
β Scribed by Durette, Philippe L.; Dorn, Conrad P.; Friedman, Arthur; Schlabach, Abner
- Book ID
- 127106670
- Publisher
- American Chemical Society
- Year
- 1982
- Tongue
- English
- Weight
- 874 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
N-Acetylmuramoyl-L-alanyl-D-isoglutamine (MDP), a fragment of bacterial peptidoglycan, is capable of replacing whole mycobacteria in complete Freund's adjuvant'. In the course of our investigation of the relationship between the chemical structure and biological activities of MDP, it has been reveal
The disaccharide of 6-O-(2-tetradecylhexadecanoyl)muramoyl dipeptide coupled through an alpha-(1----1)-alpha linkage, named in the title, and an analog bearing a single peptide moiety, have been synthesized from 2,2'-diazido-2,2'-dideoxy-alpha,alpha'-trehalose. The immunoadjuvant activities of the p