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Synthesis and hypolipidemic activity of N-pyridinyl borodipeptidylamides

โœ Scribed by M Duflos; S Robert-Piessard; JM Robert; M Andriamanamihaja; G Le Baut; B Robert; F Mainard


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
576 KB
Volume
29
Category
Article
ISSN
0223-5234

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โœ I. H. Hall; W. L. Williams Jr.; S. D. Wyrick; P. J. Voorstad ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 479 KB

Previously, a series of N-substituted indazolone derivatives proved to be effective hypolipidemic agents in rodents. The most effective agent, N2-n-butylindazolone, at 20 mg/kg/d was shown to suppress the levels of cytoplasm acetyl coenzyme A required for cholesterol and fatty acid synthesis as well