Hypolipidemic activity of N,N-dimethyl-n-octadecylamine borane in rodents
โ Scribed by Iris H. Hall; T. S. Griffin; E. L. Docks; R. J. Brotherton; George Futch
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 530 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Previously, a series of N-substituted indazolone derivatives proved to be effective hypolipidemic agents in rodents. The most effective agent, N2-n-butylindazolone, at 20 mg/kg/d was shown to suppress the levels of cytoplasm acetyl coenzyme A required for cholesterol and fatty acid synthesis as well
Lijinsky and his colleagues have reported that the N',N'-dimethyl analogues of ENU and MNU [N',N'-dimethyl-N-ethyl-N-nitrosourea (DMENU) and trimethylnitrosourea (TMNU), respectively] are carcinogenic to rats despite their extreme hydrolytic stability which would reduce or preclude generation of alk