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Synthesis and hydrolytic behaviour of glycerol-1,2-diibuprofenate-3-nitrate, a putative pro-drug of ibuprofen and glycerol-1-nitrate

✍ Scribed by Matthew J. Ingram; Humphrey A. Moynihan; Mark W. Powell; Chris Rostron


Book ID
111768651
Publisher
Pharmaceutical Press
Year
2001
Tongue
English
Weight
126 KB
Volume
53
Category
Article
ISSN
2042-7158

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Synthesis and aqueous organization of 1,
✍ J.R. Deverre; A. Gulik; Y. Letourneux; P. Couvreur; J.P. Benoit πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 English βš– 802 KB

1,3-dipalmitoyl-2-(4-aminobutyryl)glycerol β€’ HCI, a diglyceride ester of 7-aminobutyric acid (GABA), was synthesized with a good yield (46.5%). This prodrug ( 1,3-dp-GABA " HCI) was highly amphiphilic and formed stable dispersions in water. The thermodynamic parameters of the endothermic transition