Synthesis and hormonal activity of trimethylsilyl ethers of 17β-hydroxy steroids
✍ Scribed by A. A. Shishkina; T. I. Ivanenko; L. E. Golubovskaya; V. I. Mel'nikova; L. G. Sheimina; K. K. Pivnitskii
- Book ID
- 112400117
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 409 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0091-150X
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## Abstract An ion formed by loss of 56 mass units from the molecular ion is often seen in mass spectra of trimethylsilyl ethers of C~19~ and C~21~ steroids having a 3β‐hydroxy‐Δ^5^ structure and an oxo group at C‐17 or C‐20. The nature of this fragment was investigated by the use of perdeuteriotri
The mass spectra of the trimethylsilyl derivatives of 22 3P-hydroxy-A5-pregnenes have been examined with the aid of deuterium labelling and high resolution mass measurements. The influence of additional hydroxy and keto substituents on the characteristic fragment ions is discussed and fragmentation
## Abstract The mass spectra (20 eV electron energy) of a wide range of %Δ^5^‐3β‐hydroxy C~19~ steroid TMS ethers have been examined with the aid of high‐resolution mass measurements, together with deuterium and oxygen‐18 labelling data. The validity of many previously proposed fragmentation modes