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Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinazolines

✍ Scribed by Huo-Jian Wang; Cheng-Xi Wei; Xian-Qing Deng; Fu-Lan Li; Zhe-Shan Quan

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
294 KB
Volume
342
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

Several 5‐alkoxy‐tetrazolo[1,5‐a]quinazoline derivatives have been synthesized by reacting 2,4‐dichloroquinazoline with various phenols or aliphatic alcohol and then with sodium azide. The structures of these compounds have been confirmed by IR, MS, ^1^H‐NMR, and elementary analysis. Anticonvulsant activities were evaluated using the maximal electroshock (MES) test. Most of the synthesized compounds displayed weak anticonvulsant activity at a dose of 300 mg/kg. Antidepressant activities were investigated by forced swimming test. Two compounds, namely 5‐(hexyloxy)tetrazolo[1,5‐a]quinazoline and 5‐(4‐methoxyphenoxy)tetrazolo[1,5‐a]quinazoline, showed significant antidepressant activity, which decreased the immobility time by 62.2 and 51.7% at 100 mg/kg dose level.

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