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Synthesis and evaluation of the glycosidase inhibitory activity of 5-hydroxy substituted isofagomine analogues

โœ Scribed by Matin, Mohammed M.; Sharma, Tarun; Sabharwal, Sushma G.; Dhavale, Dilip D.


Book ID
119956044
Publisher
Royal Society of Chemistry
Year
2005
Tongue
English
Weight
173 KB
Volume
3
Category
Article
ISSN
1477-0520

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Synthesis and glycosidase inhibitory act
โœ Seiichiro Ogawa; Shigeo Fujieda; Yuko Sakata; Masahiro Ishizaki; Seiichi Hisamat ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 139 KB

Chemical modification of 5a-carba-b-dl-fucopyranosylamine (3) generated six N-substituted derivatives 9a-f, among which N-octyl 9b, decyl 9c, and phenylbutyl ones 9f were found to be very strong b-galactosidase as well as b-glucosidase inhibitors. The inhibitory activity appeared attributable to d-e