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Synthesis and evaluation of six-membered GDP-iminocyclitol

✍ Scribed by Michael L Mitchell; Lac V Lee; Chi-Huey Wong

Book ID: 104251513
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 61 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)01108-5

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✦ Synopsis

Fructose-diphosphate aldolase was employed in the chemoenzymatic synthesis of six-membered GDP-iminocyclitols. These compounds were evaluated for activity against a-1,3-fucosyltransferases and found to be potent inhibitors.

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