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Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4′-piperidine] analogs

✍ Scribed by Yoshikazu Uto; Yuko Ueno; Yohei Kiyotsuka; Yuriko Miyazawa; Hitoshi Kurata; Tsuneaki Ogata; Makiko Yamada; Tsuneo Deguchi; Masahiro Konishi; Toshiyuki Takagi; Satoko Wakimoto; Jun Ohsumi

Book ID
108116482
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
462 KB
Volume
45
Category
Article
ISSN
0223-5234

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ChemInform Abstract: Novel Spiropiperidi
ChemInform Abstract: Novel Spiropiperidine-Based Stearoyl-CoA Desaturase-1 Inhibitors: Identification of 1′-{6-[5-(Pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl] pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro [chromene-2,4′-piperidine].
✍ Yoshikazu Uto; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 18 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Synthesis and antibacterial activity of
Synthesis and antibacterial activity of novel series of 2-(p-tolyloxy)-3-(5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)quinoline
✍ Ratnadeep S. Joshi; Priyanka G. Mandhane; Wajid Khan; Charansingh H. Gill 📂 Article 📅 2011 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 140 KB 👁 1 views

## Abstract A new series of 2‐(__p__‐tolyloxy)‐3‐(5‐(pyridin‐4‐yl)‐1,3,4‐oxadiazol‐2‐yl)quinoline were synthesized from oxidative cyclization of __N__′‐((2‐(__p__‐tolyloxy)quinoline‐3‐yl)methylene)isonicotinohydrazide in DMSO/I~2~ at reflux condition for 3–4 h. The structures of the new compounds w