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Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives

✍ Scribed by Kazutaka Nakamoto; Itaru Tsukada; Keigo Tanaka; Masayuki Matsukura; Toru Haneda; Satoshi Inoue; Norio Murai; Shinya Abe; Norihiro Ueda; Mamiko Miyazaki; Naoaki Watanabe; Makoto Asada; Kentaro Yoshimatsu; Katsura Hata

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 297 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.005

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✦ Synopsis

Quinoline amide, azaindole amide and pyridine amides were synthesized and tested for in vitro antifungal activity against fungi. These synthesized amides have potent antifungal activity against Candida albicans and Aspergillus fumigatus. Our results suggest that hetero ring amides may be potent antifungal agents that operate by inhibiting the function of Gwt1 protein in the GPI biosynthetic pathway.

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