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Synthesis and bioactivities of steroid derivatives as antifungal agents

✍ Scribed by Sung-Kee Chung; Chung Hwan Ryoo; Hong Woon Yang; Jeung-Yeop Shim; Myung Goo Kang; Ki Wha Lee; Heui Il Kang

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
832 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

A series of lanostemi and cholesterol derivatives with modified side chain ~ which might interfere with sterol C24-methyltransfera~ in the ergosterol biosynthesis as substrate analogs, have been synthesized. The in vitro bioassay studies have shown that some of these compounds, in imtticolar with C24amino-and thio-functionalities, possess potent antifungal activities, in vivo. Bioassays have also been carried out for the leading compounds.

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## Abstract A new series of chalcones, pyrimidines, and imidazolinone is described; chalcones (**4a**, **4b**, **4c**, **4d**, **4e**, **4f**, **4g**, **4h**, **4i**, **4j**, **4k**, **4l**, **4m**, **4n**, **4o**) were prepared from the lead 4‐[2‐(5‐ethylpyridin‐2‐yl)ethoxy]benzaldehyde. Pyrimidin