Synthesis and Evaluation of Novel Acyclovir Phosphoramidates as Anti-HIV Agents
โ Scribed by Davide Carta; Christopher McGuigan; Leonid Margolis; Jan Balzarini
- Book ID
- 113458028
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 88 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0166-3542
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๐ SIMILAR VOLUMES
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Thirty-eight tea polyphenols were evaluated for their inhibitory effect against HIV replication in H9 lymphocyte cells. 8-C-Ascorbyl (-)-epigallocatechin (13) and theasinensin-D (32) demonstrated relatively potent anti-HIV activity with EC50 values of 4 and 8 tlg/mL and therapeutic indexes of 9.5 an