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Evaluation of tea polyphenols as anti-HIV agents

✍ Scribed by Fumio Hashimoto; Yoshiki Kashiwada; Gen-ichiro Nonaka; Itsuo Nishioka; Toshihiro Nohara; L.Mark Cosentino; Kuo-Hsiung Lee

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 237 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00095-9

No coin nor oath required. For personal study only.

✦ Synopsis

Thirty-eight tea polyphenols were evaluated for their inhibitory effect against HIV replication in H9 lymphocyte cells. 8-C-Ascorbyl (-)-epigallocatechin (13) and theasinensin-D (32) demonstrated relatively potent anti-HIV activity with EC50 values of 4 and 8 tlg/mL and therapeutic indexes of 9.5 and 5, respectively.

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