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Synthesis and Evaluation of New Antagonists of Bacterial Quorum Sensing in Vibrio harveyi

✍ Scribed by Hanjing Peng; Yunfeng Cheng; Nanting Ni; Minyong Li; Gaurav Choudhary; Han Ting Chou; Chung-Dar Lu; Phang C. Tai; Binghe Wang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
478 KB
Volume
4
Category
Article
ISSN
1860-7179

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✦ Synopsis

Abstract

Bacterial quorum sensing has received much attention in recent years because of its relevance to pathological events such as biofilm formation. Based on the structures of two lead inhibitors (IC~50~: 35–55 μM) against autoinducer‐2‐mediated quorum sensing identified through virtual screening, we synthesized 39 analogues and examined their inhibitory activities. Twelve of these new analogues showed equal or better inhibitory activities than the lead inhibitors. The best compound showed an IC~50~ value of ∼6 μM in a whole‐cell assay using Vibrio harveyi as the model organism. The structure–activity relationship is discussed herein.

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ChemInform Abstract: Inhibitors and Anta
ChemInform Abstract: Inhibitors and Antagonists of Bacterial Quorum Sensing
✍ Nanting Ni; Minyong Li; Junfeng Wang; Binghe Wang 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 15 KB 👁 2 views

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