✦ LIBER ✦

Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors

✍ Scribed by Gu, Zi Qiang; Wong, Garry; Dominguez, Celia; de Costa, Brian R.; Rice, Kenner C.; Skolnick, Phil

Book ID: 120008260
Publisher: American Chemical Society
Year: 1993
Tongue: English
Weight: 865 KB
Volume: 36
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00060a007

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of [3H]tert-butyl 8-chloro-5,6

Synthesis of [3H]tert-butyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4h-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate, a selective, high affinity ligand for the diazepam insensitive (DI) subtype of the benzodiazepine receptor

✍ Zi-Qiang Gu; Brian R. de Costa; Garry Wong; Kenner C. Rice; Phil Skolnick 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 388 KB 👁 1 views

## Abstract The preparation of [^3^H]‐labelled tert‐butyl 8‐chloro‐5,6‐dihydro‐5‐methyl‐6‐oxo‐4H‐imidazo[1,5‐a][1,4]benzodiazepine 3‐carboxylate (TCIB, 6), a high affinity ligands for the diazepam insensitive (DI) subtype of the benzodiazepine receptor (BZR) is described. Synthesis of [^3^H]TCIB wa

5-Aryl-imidazo[2,1-c][1,4]benzodiazepine

5-Aryl-imidazo[2,1-c][1,4]benzodiazepine Derivatives as Tricyclic Constrained Analogues of Diazepam and Ro5-4864. Synthesis and Binding Properties at Peripheral and Central Benzodiazepine Receptors.

✍ E. Rizzetto; S. Castellano; C. Florio; M. Vadori; G. Stefancich 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

3-Phenyl-Substituted Imidazo[1,5- a ]qui

3-Phenyl-Substituted Imidazo[1,5- a ]quinoxalin-4-ones and Imidazo[1,5- a ]quinoxaline Ureas That Have High Affinity at the GABA A /Benzodiazepine Receptor Complex †

✍ Jacobsen, E. Jon; Stelzer, Lindsay S.; Belonga, Kenneth L.; Carter, Donald B.; I 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 501 KB

Synthesis of [123I]tert-butyl 8-iodo-5,6

Synthesis of [123I]tert-butyl 8-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate, a potential SPECT imaging agent for diazepam-insensitive (DI) benzodiazepine receptors

✍ Xiao-Shu He; Dorota Matecka; Kan Sam Lee; Zi-Qiang Gu; Kenner C. Rice; Garry Won 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 355 KB 👁 1 views

## Abstract [^123^I]__tert__‐Butyl 8‐iodo‐5,6‐dihydro‐5‐methyl‐6‐oxo‐4__H__‐imidazo [1,5‐a][1,4]benzodiazepine 3‐carboxylate ([^123^I]3), a high affinity and selective radioligand for the diazepam insensitive (DI) benzodiazepine receptor was synthesized in 2 steps from __tert__‐butyl 8‐bromo‐5,6‐di

High-Affinity Partial Agonist Imidazo[1,

High-Affinity Partial Agonist Imidazo[1,5- a ]quinoxaline Amides, Carbamates, and Ureas at the γ-Aminobutyric Acid A/Benzodiazepine Receptor Complex †

✍ Jacobsen, E. Jon; TenBrink, Ruth E.; Stelzer, Lindsay S.; Belonga, Kenneth L.; C 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 598 KB

Labelling of diazepam-sensitive and -ins

Labelling of diazepam-sensitive and -insensitive benzodiazepine receptors with [3H]tert-butyl-8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazol[1,5-a][1,4]benzodiazepine 3-carboxylate (ZG-63)

✍ Garry Wong; Zi-Qiang Gu; Brian de Costa; Phil Skolnick 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 638 KB