𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Labelling of diazepam-sensitive and -insensitive benzodiazepine receptors with [3H]tert-butyl-8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazol[1,5-a][1,4]benzodiazepine 3-carboxylate (ZG-63)

✍ Scribed by Garry Wong; Zi-Qiang Gu; Brian de Costa; Phil Skolnick

Book ID
113398557
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
638 KB
Volume
247
Category
Article
ISSN
0922-4106

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of [3H]tert-butyl 8-chloro-5,6
Synthesis of [3H]tert-butyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4h-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate, a selective, high affinity ligand for the diazepam insensitive (DI) subtype of the benzodiazepine receptor
✍ Zi-Qiang Gu; Brian R. de Costa; Garry Wong; Kenner C. Rice; Phil Skolnick 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 388 KB 👁 1 views

## Abstract The preparation of [^3^H]‐labelled tert‐butyl 8‐chloro‐5,6‐dihydro‐5‐methyl‐6‐oxo‐4H‐imidazo[1,5‐a][1,4]benzodiazepine 3‐carboxylate (TCIB, 6), a high affinity ligands for the diazepam insensitive (DI) subtype of the benzodiazepine receptor (BZR) is described. Synthesis of [^3^H]TCIB wa

Synthesis of [123I]tert-butyl 8-iodo-5,6
Synthesis of [123I]tert-butyl 8-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate, a potential SPECT imaging agent for diazepam-insensitive (DI) benzodiazepine receptors
✍ Xiao-Shu He; Dorota Matecka; Kan Sam Lee; Zi-Qiang Gu; Kenner C. Rice; Garry Won 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 355 KB 👁 1 views

## Abstract [^123^I]__tert__‐Butyl 8‐iodo‐5,6‐dihydro‐5‐methyl‐6‐oxo‐4__H__‐imidazo [1,5‐a][1,4]benzodiazepine 3‐carboxylate ([^123^I]3), a high affinity and selective radioligand for the diazepam insensitive (DI) benzodiazepine receptor was synthesized in 2 steps from __tert__‐butyl 8‐bromo‐5,6‐di

Synthesis of carbon-14 labeled 1,4-benzo
Synthesis of carbon-14 labeled 1,4-benzodiazepines. III. 2-allyloxy-amino-7-chloro-5-(2-chlorophenyl)-3h-l,4-benzodiazepine-2-14C, 8-chloro-1-dimethylamino-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-3a-14C, and 8-chloro-2,4-dihydro-2-methyl-6-phenyl-1H-s-triazolo[4,3-a] [1,4]benzodiazepin-l-one-3a-14
✍ Richard S. P. Hsi; Tommy D. Johnson 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 281 KB 👁 1 views

## Abstract A group of radioactive 1,4‐benzodiazepine derivatives have been synthesized from glycine‐1‐^14^C. The subject compounds are labeled with carbon‐14 in the 2‐position of the 1,4‐benzodiazepine ring system.

The metabolism of iodine-123 labelled 3-
The metabolism of iodine-123 labelled 3-(5-cyclopropyl-1,2,4-oxadiazo-3-yl)-7-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine (NNC 13–8241) measured in human plasma is only minor
✍ Kari K. Åkerman; Kim A. Bergström; Christer Halldin; Simo Lötjönen; Meixiang Yu; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 130 KB 👁 2 views

The imidazobenzodiazepine derivate 123 I-labelled 3-(5-cyclopropyl-1,2,4-oxadiazo-3-yl)-7-iodo-5,6-dihydro-5methyl-6-oxo-4H-imidazo [1,5-a][1,4]-benzodiazepine (NNC 13±8241) is a partial benzodiazepine agonist and binds with a high anity to the benzodiazepine receptor. The favourable kinetic propert