Initial human studies with single-photon emission tomography using iodine-123 labelled 3-(5-cyclopropyl-1,2,4-oxadiazo-3-yl)-7-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]-benzodiazepine (NNC 13-8241)

The metabolism of iodine-123 labelled 3-

The metabolism of iodine-123 labelled 3-(5-cyclopropyl-1,2,4-oxadiazo-3-yl)-7-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine (NNC 13–8241) measured in human plasma is only minor

✍ Kari K. Åkerman; Kim A. Bergström; Christer Halldin; Simo Lötjönen; Meixiang Yu; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 130 KB 👁 2 views

The imidazobenzodiazepine derivate 123 I-labelled 3-(5-cyclopropyl-1,2,4-oxadiazo-3-yl)-7-iodo-5,6-dihydro-5methyl-6-oxo-4H-imidazo [1,5-a][1,4]-benzodiazepine (NNC 13±8241) is a partial benzodiazepine agonist and binds with a high anity to the benzodiazepine receptor. The favourable kinetic propert