Synthesis and evaluation of biological activity of new aminoadamantane amides containing hydroxycinnamoyl moiety
β Scribed by Maya G. Chochkova; Asya P. Georgieva; Galya I. Ivanova; Ivanka G. Stankova; Tsenka S. Milkova
- Book ID
- 113458630
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 704 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0166-3542
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## Abstract A series of novel pyrazole amides **J1**, **J2**, **J3**, **J4**, **J5**, **J6**, **J7**, **J8**, **J9**, **J10**, **J11**, **J12**, **J13**, **J14**, **J15** containing an Ξ±βaminophosphonate moiety were synthesized and subsequently characterized by spectral (IR, ^1^Hβ, ^13^Cβ, ^31^Pβ,
2-adamantanole was the protecting group of the aspartate 13-COOH moiety during the peptide synthesis and survived the final peptide cleavage and deprotection carried out under controlled conditions. MEN 10586 showed an agonist activity comparable to that of the parent compound MEN 10210 at NK~ and N