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Synthesis and biological activity studies of new hybrid molecules containing tryptamine moiety

โœ Scribed by Hakan Bektas; Ahmet Demirbas; Neslihan Demirbas; Sengul Alpay Karaoglu


Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
348 KB
Volume
21
Category
Article
ISSN
1054-2523

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2-adamantanole was the protecting group of the aspartate 13-COOH moiety during the peptide synthesis and survived the final peptide cleavage and deprotection carried out under controlled conditions. MEN 10586 showed an agonist activity comparable to that of the parent compound MEN 10210 at NK~ and N