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Synthesis and evaluation of antiviral activity of 2′-deoxyuridines with 5-methylene-2-thiohydantoin substituents in the 5-position

✍ Scribed by A. A. El-Barbary; A. I. Khodair; E. B. Pedersen; C. Nielsen

Publisher
Springer Vienna
Year
1994
Tongue
English
Weight
360 KB
Volume
125
Category
Article
ISSN
0026-9247

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Synthesis of Uridine with Methylene-2-th
Synthesis of Uridine with Methylene-2-thiohydantoin as 5-Substituent
✍ El-Barbary, Ahmed A. ;Khodair, Ahmed I. ;Pedersen, Erik B. ;Nielsen, Claus 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 241 KB

## Abstract 5‐Formyl‐1‐(2,3,5‐tri‐__O__‐acetyl‐β‐D‐ribofuranosyl)uracil (4) was synthesized from 5‐formyluracil (2) and 1,2,3,5‐tetra‐__O__‐acetyl‐β‐D‐ribofuranose (3) and condensed with 2‐thiohydantoin derivatives 5 by using piperidine as the catalyst to give 5‐(uridin‐5‐ylmethylene)‐2‐thiohydanto