Synthesis and evaluation of antimicrobial properties of amidinoazaandrostanes and guanidinoazaandrostanes
✍ Scribed by Norman J. Doorenbos; Jack C. Kim
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 335 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3549
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The synthesis and first antimicrobial evaluation of farnesyl diphosphate mimetics are described. Several analogues (10, 12, 13, and 20) are inhibitors of Candida albicans, Shizosaccharomyces pombe, and Saccharomyces cerevisiae. The activities of analogues 10, 12, and 13, which contain a omega-phenyl
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## Abstract 6‐Amino‐5‐imino‐pyrazolo[4′,3′:5,6]pyrano[2,3‐__d__]pyrimidine derivative **4** and pyrazolo‐[4′,3′:5,6]pyrano[2,3‐__d__]pyrimidin‐5‐ylhydrazine derivative **5** were prepared starting from 6‐amino‐3‐methyl‐4‐(__p__‐nitrophenyl)‐2,4‐dihydropyrano[2,3‐__c__]pyrazole‐5‐carbonitrile **1**.