Synthesis, Isomerization, and Antimicrobial Evaluation of Some Pyrazolopyranotriazolopyrimidine Derivatives

✍ Scribed by Ahmed H. Shamroukh; Magdi E. A. Zaki; Eman M. H. Morsy; Faiza M. Abdel-Motti; Farouk M. E. Abdel-Megeid

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 760 KB
• Volume: 340
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200700007

✦ Synopsis

Abstract

6‐Amino‐5‐imino‐pyrazolo[4′,3′:5,6]pyrano[2,3‐d]pyrimidine derivative 4 and pyrazolo‐[4′,3′:5,6]pyrano[2,3‐d]pyrimidin‐5‐ylhydrazine derivative 5 were prepared starting from 6‐amino‐3‐methyl‐4‐(p‐nitrophenyl)‐2,4‐dihydropyrano[2,3‐c]pyrazole‐5‐carbonitrile 1. The synthesis and structure characterization of 9,11‐dihydropyrazolo[4′,3′:5,6]pyrano[3,2‐e][1,2,4]triazolo[4,3‐c]pyrimidine derivatives 7 and 9 and their isomerization to 9,11‐dihydropyrazolo[4′,3′:5,6]pyrano[3,2‐e] [1,2,4]triazolo[1,5‐c]pyrimidine derivatives 6 and 8, respectively, under different suitable reaction conditions are reported. Moreover, the synthesis of 9,11‐dihydropyrazolo[4′,3′:5,6]pyrano[3,2‐e] tetrazolo[1,5‐c]pyrimidine derivative 14 and N^9^‐acyclic nucleoside 15 are described. Some of the prepared products showed potent antimicrobial activity.