Synthesis and Evaluation of 5-Phenyl-1 H -1,4-benzodiazepin-2(3 H )-one-Based Palladium Complexes as Precatalysts in C−C Bond Forming Reactions
✍ Scribed by Spencer, John; Sharratt, David P.; Dupont, Jairton; Monteiro, Adriano L.; Reis, Vinicius I.; Stracke, Marcelo P.; Rominger, Frank; McDonald, Iain M.
- Book ID
- 121875829
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 176 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0276-7333
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In order to more easily study the absorption, excretion, and distribution patterns of 7-chloro-1 -(cyclopropylmethyl)-5-phenyl-1 H-1,4-benzodiazepin-
## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des
## Abstract The synthesis from carbon‐^14^C dioxide of 1, 3‐dihydro‐1‐methyl‐7‐nitro‐5‐phenyl‐2H‐1, 4‐benzodiazepin‐2‐one‐5‐^14^C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was near
Tema~epam-2-'~C, 7-Chloro-1,3-ihydro-3-hydroxy-1 -methyl-5-phenyl-2H-1,4-benzodiazepin-2-one--"C, was prepared in a f ive-step synthesis. Chl~roacetic-l-~~C acid was converted to the acid chloride with thionyl chloride. The acid chloride was allowed to react with 2-methylamino-5-chloro-benzophenone