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Synthesis and evaluation of 5′ alkyl ester prodrugs of zidovudine for directed lymphatic delivery

✍ Scribed by David C. Bibby; William N. Charman; Susan A. Charman; Magdy N. Iskander; Christopher J.H. Porter


Book ID
114248458
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
827 KB
Volume
144
Category
Article
ISSN
0378-5173

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Alkyl esters of ketorolac were synthesized as potential prodrugs for transdermal delivery and evaluated to determine the relationship between their skin permeation characteristics and their physicochemical properties. Solubility of the prodrugs in various vehicles was determined at room temperature