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Synthesis and Evaluation of 4/5-Hydroxy-2,3-diaryl(substituted)-cyclopent-2-en-1-ones as cis -Restricted Analogues of Combretastatin A-4 as Novel Anticancer Agents

โœ Scribed by Gurjar, Mukund K.; Wakharkar, Radhika D.; Singh, Anu T.; Jaggi, Manu; Borate, Hanumant B.; Shinde, Popat D.; Verma, Ritu; Rajendran, Praveen; Dutt, Sarjana; Singh, Gurvinder; Sanna, Vinod K.; Singh, Manoj K.; Srivastava, Sanjay K.; Mahajan, Vishal A.; Jadhav, Vinod H.; Dutta, Kakali; Krishnan, Karthik; Chaudhary, Anika; Agarwal, Shiv K.; Mukherjee, Rama; Burman, Anand C.


Book ID
120983582
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
312 KB
Volume
50
Category
Article
ISSN
0022-2623

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## Abstract A series of novel 4__ฮฒ__โ€[(4โ€substituted)โ€1,2,3โ€triazolโ€1โ€yl]podophyllotoxin derivatives were synthesized by employing Cu^I^โ€catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HTโ€29, HCTโ€15, 502713, HOPโ€62, Aโ€549, MCFโ€