Synthesis and Evaluation of 4/5-Hydroxy-2,3-diaryl(substituted)-cyclopent-2-en-1-ones as cis -Restricted Analogues of Combretastatin A-4 as Novel Anticancer Agents
โ Scribed by Gurjar, Mukund K.; Wakharkar, Radhika D.; Singh, Anu T.; Jaggi, Manu; Borate, Hanumant B.; Shinde, Popat D.; Verma, Ritu; Rajendran, Praveen; Dutt, Sarjana; Singh, Gurvinder; Sanna, Vinod K.; Singh, Manoj K.; Srivastava, Sanjay K.; Mahajan, Vishal A.; Jadhav, Vinod H.; Dutta, Kakali; Krishnan, Karthik; Chaudhary, Anika; Agarwal, Shiv K.; Mukherjee, Rama; Burman, Anand C.
- Book ID
- 120983582
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 312 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-2623
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## Abstract A series of novel 4__ฮฒ__โ[(4โsubstituted)โ1,2,3โtriazolโ1โyl]podophyllotoxin derivatives were synthesized by employing Cu^I^โcatalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HTโ29, HCTโ15, 502713, HOPโ62, Aโ549, MCFโ