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Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents

โœ Scribed by Shyam, Krishnamurthy; Penketh, Philip G.; Divo, Alan A.; Loomis, Regina H.; Patton, Curtis L.; Sartorelli, Alan C.

Book ID
127058526
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
948 KB
Volume
33
Category
Article
ISSN
0022-2623

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โœ Giuseppe Giordano; Krishnamurthy Shyam; Alan C. Sartorelli; Walter J. McMurray ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 313 KB

Several 1,2,2-tris(sulfonyl)hydrazines, conceived as prodrugs of 1,2bis(sulfonyl)hydra~nes and synthesized as potential antineoplastic and trypanocidal drugs, were analyzed by m a s spectrometry as part of the confirmation of the structure of these compounds. Since these compounds showed activity ag