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Synthesis and Erosion Properties of PEG-Containing Polyanhydrides

✍ Scribed by Sijian Hou; Laurie K. McCauley; Peter X. Ma

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
335 KB
Volume
7
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

To tailor the erosion rate of polyanhydrides while retaining their surface erosion characteristics, new three‐component polyanhydrides of sebacic acid, 1,3‐bis(p‐carboxyphenoxy)propane and poly(ethylene glycol) were synthesized. The hydrophilicity of the polymer increased and its mechanical strength decreased with increasing PEG content. Correspondingly, the erosion rate increases with increasing PEG content, whereas it decreases with increasing specimen thickness. This indicates that the incorporation of poly(ethylene glycol) into traditional two‐component polyanhydrides retains their surface erosion properties while making the erosion rate tunable. The new polyanhydrides hold potential for drug delivery applications.

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