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Synthesis and characterization of novel polyanhydrides with tailored erosion mechanisms

✍ Scribed by María P. Torres; Brandon M. Vogel; Balaji Narasimhan; Surya K. Mallapragada

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
171 KB
Volume
76A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

We have designed a new synthesis route to create polyanhydrides based on monomers that contain hydrophilic entities within highly hydrophobic backbones. The method results in polyanhydrides that can be easily processed into drug‐containing tablets. The synthesis, characterization, and erosion studies of polyanhydride copolymers based on 1,6‐bis(p‐carboxyphenoxy)hexane (CPH), which is highly hydrophobic, and 1,8‐bis(p‐carboxyphenoxy)‐3,6‐dioxaoctane (CPTEG), which has hydrophilic oligomeric ethylene glycol segments in the monomer unit, was performed using a combination of molecular spectroscopy, thermal analysis, gravimetry, and scanning electron microscopy. The studies demonstrate that by increasing the CPH content in the CPTEG:CPH copolymers, the erosion of the system can be tailored from bulk‐eroding to surface‐eroding mechanism. These systems have promise as protein carriers. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

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