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Synthesis and DNA-sequence selectivity of a series of mono- and difunctional 9-aminoacridine nitrogen mustards

✍ Scribed by Kohn, Kurt W.; Orr, Ann; O'Connor, Patrick M.; Guziec, Lynn James; Guziec, Frank S.


Book ID
126974535
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
716 KB
Volume
37
Category
Article
ISSN
0022-2623

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## Abstract Bis‐9‐acridinyl derivatives 1–3 containing mono‐, di‐and tetra‐viologen units as a rigid connector were synthesized. The binding studies of these intercalators for natural and synthetic DNAs showed that these compounds act as bis‐intercalators where viologen moieties lie in the minor gr