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Synthesis and diuretic activity of imidazo[2,1-b]thiazole acetohydrazones

✍ Scribed by Aldo Andreani; Mirella Rambaldi; Giuseppe Mascellani; Pierluigi Rugarli

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 352 KB
Volume: 22
Category: Article
ISSN: 0223-5234
DOI: 10.1016/0223-5234(87)90169-3

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## Abstract Spiro[5,5]undecane‐3‐one 1 was converted to 4,7‐dihydrospiro[benzo[__d__]thiazole‐6(5__H__),1′‐cyclohexane]‐2‐amine 3, which is condensed with bromomethyl (halo)phenyl ketones and cyclized to compounds 5a‐5c. The X‐ray crystallography of the 5b reveals that formation route for 5 is __vi