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Synthesis and Cytotoxicity Studies of Novel 2-Hydrazonylpyrido[2,3-b]pyrazin-3(4H)-ones

✍ Scribed by Guogang Zhang; Yajing Liu; Shuobing Wang; Chuan Zhou; Qingchang Huang; Ping Gong

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
197 KB
Volume
345
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

In an attempt to develop potent antitumor agents, a series of novel 2‐hydrazonylpyrido[2,3‐b]pyrazin‐3(4__H__)‐one derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, MDA‐MB‐231 and HT‐29 cell lines in vitro. Pharmacological data indicated that five of the target compounds showed cytotoxicity against A549 cell line below a concentration of 1 µM. Compound 15g was the most potent one with IC~50~ values of 0.19, 2.11 and 2.15 µM against A549, MDA‐MB‐231 and HT29 cell lines, respectively.

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