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Synthesis and cytotoxicity of silylalkylthio-substituted N-heterocycles and their hydroselenites

✍ Scribed by Pavel Arsenyan; Kira Rubina; Irina Shestakova; Edgars Abele; Ramona Abele; Ilona Domracheva; Alena Nesterova; Juris Popelis; Edmunds Lukevics

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
127 KB
Volume
17
Category
Article
ISSN
0268-2605

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✦ Synopsis

Abstract

New hydroselenites of the different silylalkylthio‐substituted N‐heterocycles have been prepared by the reaction of selenium dioxide with N‐heterocycles in an aqueous medium. Their structure was confirmed by ^1^H, ^13^C, and ^77^Se NMR data. Most of these silylalkylthio‐substituted N‐heterocycles and their hydroselenites have an expressed cytotoxic activity on the MG‐22A (mouse hepatoma), HT‐1080 (human fibrosarcoma), B16 (mouse melanoma), and Neuro 2A (mouse neuroblastoma) cell lines. Some of the hydroselenites exhibit free‐radical protection simultaneously with a high cytotoxic effect. The substances studied were also active __in vivo__against sarcoma S‐180. Copyright © 2003 John Wiley & Sons, Ltd.

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## Abstract Mixed N‐heterocyclic carbene‐substituted phosphine and phosphite complexes of rhodium were prepared, starting from [Rh(COE)~2~Cl]~2~ (COE=cyclooctene) by addition of free N‐heterocyclic carbenes (NHC) and PR~3~. All new complexes were characterized by spectroscopy. In addition, the stru