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Synthesis and Cytotoxic Evaluation of a Series of Resveratrol Derivatives

✍ Scribed by Ban-Feng Ruan; Xian-Feng Huang; Hui Ding; Chen Xu; Hui-Ming Ge; Hai-Liang Zhu; Ren-Xiang Tan

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 79 KB
Volume: 3
Category: Article
ISSN: 1612-1872
DOI: 10.1002/cbdv.200690106

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✦ Synopsis

A total of 17 resveratrol ( ¼ (E)-5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol) derivatives were synthesized from resveratrol (RES) through a facile approach. Among them, 13 compounds, 2 and 6 -17, were reported for the first time, while 1 and 3 -5 had already been reported several years ago. The cytotoxic activities of these compounds were evaluated against human nasopharyngeal epidermoid tumor cell line KB, and compounds 1 and 8 -11 showed strong anticancer activities in vitro, comparable with that of 5-fluorouracil, an anticancer drug. On the basis of the experimental data obtained, structure -activity relationships are discussed.

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