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Synthesis and cytotoxic activities of 4,5-diarylisoxazoles

✍ Scribed by Chang-Ming Sun; Lee-Gin Lin; Hsi-Jung Yu; Chih-Yu Cheng; Ya-Chuan Tsai; Chi-Wei Chu; Yi-Hui Din; Yat-Pang Chau; Ming-Jaw Don

Book ID
108074216
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
133 KB
Volume
17
Category
Article
ISSN
0960-894X

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

A convenient synthesis of 5-alkylthio-3,
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## Abstract magnified image Palladium‐catalyzed coupling reaction was found effective for rapid access to pharmacologically interesting 3,4‐diarylisoxazoles derivatives as selective COX‐2 inhibitors. Thus, the coupling reaction between 5‐alkylthio‐3‐aryl‐4‐iodoisoxazoles and arylboronic acids affo