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Synthesis and cyclization of N-(2-hydroxyphenyl)-and N-(2-benzyloxyphenyl)-Β-alanines

✍ Scribed by V. Yu. Mitskyavichyus; R. S. Baltrushis; Z. -I. G. Beresnevichyus

Publisher
Springer US
Year
1991
Tongue
English
Weight
371 KB
Volume
27
Category
Article
ISSN
0009-3122

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✦ Synopsis

N-Substituted ~.alanines have been synthesized by treating o-aminophenol or o-benzyloxyanUine with acrylic, raethacrylic, or crotonic acids. Their cyclization to 2-benzoxazolinones and dihydro.2,4(1H,3H)pyrimidinediones has been studied.

We have shown [1] that, in contrast to N-aryl-B-alanines (which react with urea in acid media to form 1aryldihydro-2,4(1H,3H)-pyrimidinediones [2]), N-(2-hydroxyphenyl)-/9-alanine and its methyl homolog react under these conditions to give 3-(3-benzoxazolonyl)propanoic acid or its methyl homolog. There is a connected interest in synthesizing 1 -(2-hydroxyphenyl)dihydro-2,4(1 H,3H)-pyrimidinediones by cyclization of 1-(2-hydroxyphenyl)-#-alanines (or their preparation by other means) and to examine the process by which they are formed.

📜 SIMILAR VOLUMES

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