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Synthesis and Crystal Structures of Two 9-(2-Bromoethyl)-Substituted 7-Deazapurines

✍ Scribed by Simona Asaftei; Martin Reichelt; Hans Reuter; Helmut Rosemeyer

Publisher
John Wiley and Sons
Year
2009
Tongue
German
Weight
404 KB
Volume
92
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The 7‐(2‐bromoethyl) derivatives, 2a and 2b, of 4‐chloro‐7__H__‐pyrrolo[2,3‐d]pyrimidine (1a) and 4‐chloro‐7__H__‐pyrrolo[2,3‐d]pyrimidin‐2‐amine (1b) were synthesized by nucleobase anion alkylation (NaH, DMF) and crystallized. X‐Ray analyses of both compounds were performed, and they revealed significantly different positioning of the side chain relative to the heterocyclic ring, depending on the substituent (H or NH~2~) at C(2).

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