𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and Conformational Studies of a β-Turn Mimetic Incorporated in Leu-enkephalin

✍ Scribed by Blomberg, David; Hedenström, Mattias; Kreye, Paul; Sethson, Ingmar; Brickmann, Kay; Kihlberg, Jan

Book ID
120416055
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
229 KB
Volume
69
Category
Article
ISSN
0022-3263

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of a novel β-turn mimetic and
Synthesis of a novel β-turn mimetic and its incorporation in Leu-enkephalin
✍ Paul Kreye; Jan Kihlberg 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 223 KB

A conformationaily restricted 13-turn mimetic, in which an ethylene bridge replaces the intramolecular hydrogen bond between residues i and i + 3 of 13-turns, has been prepared and incorporated in Leu-enkephalin. Amino acids and a-bromoaeids were used as building blocks in the synthesis of the mimet

Synthesis and structure of a hydrophilic
Synthesis and structure of a hydrophilic β-turn mimetic
✍ Armin Geyer; Dirk Bockelmann; Kerstin Weissenbach; Helmut Fischer 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 143 KB

and L-cysteine form the thiazolidine lactam 2a in a stereoselective and quantitative reaction. Condensation of 5-azido-5-deoxy-D-glucurono-3,6-1actone (lb) with L-cysteine methyl ester followed by the reduction of the azido group yields the rigid [3-tum mimetic 2d in a minimum of reaction steps.