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Synthesis and Conformational Analysis of Optically Active Poly(β-peptides)

✍ Scribed by Cheng, Jianjun; Deming, Timothy J.


Book ID
126960273
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
89 KB
Volume
34
Category
Article
ISSN
0024-9297

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The homochiral 3-amino-1-(4-methoxyphenyl)-4-phenyl-βlactam (ϵ Alm) was conjugated with Boc-Ala to give Ala-Alm (9) after Boc deprotection (Boc = tert-butoxycarbonyl, Ala = alanine). Coupling of Fc-COOH (1) and Boc-Fca (10) with "dipeptide" 9 resulted in the formation of Fc-CO-Ala-Alm ( ) and the tr