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Synthesis and conformational analysis of 1-substituted-4a-(4-chlorophenyl)-1,2,3,4-tetrahydro-4aH-pyrimido[6,1-a]isoindol-9-one

✍ Scribed by Eberle, Marcel K.; Brzechffa, Leszek; Shapiro, Michael J.


Book ID
126311898
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
258 KB
Volume
52
Category
Article
ISSN
0022-3263

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Synthesis of sterically hindered 4a, 9a-
✍ JoseΒ΄Gonzalo RodriΒ΄guez; AnahiΒ΄ Urrutia πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 382 KB

The reaction of 4a-methyl-l,2,3,4-tetrahydrocarbazole (1) with organolithium reagents affords the sterically hindered alkyl, aryl or alkenyl cis-4a-methyl-9a-substituted-l,2,3,4,4a,9ahexahydrocarbazole derivatives (2) in excellent yields. Two diastereomeric pairs were isolated for the 9a-see-butyl d