Synthesis and conformation of a novel bridged nucleoside with S-type sugar puckering, trans-3′,4′-BNA monomer
✍ Scribed by Satoshi Obika; Mitsuaki Sekiguchi; Tomohisa Osaki; Nao Shibata; Miyuki Masaki; Yoshiyuki Hari; Takeshi Imanishi
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 98 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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A novel bridged nucleic acid monomer, 3%-amino-3%-deoxy-5-methyl-3%-N,4%-C-methyleneuridine, was successfully synthesized via a useful and convenient azetidine ring formation under Staudinger's conditions. A 1 H NMR experiment and a PM3 calculation revealed that the sugar moiety of the novel bridged
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