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Synthesis and circular dichroism characterization of L-azetidine-2-carboxylic acid cyclic peptides

✍ Scribed by R. Boni; A. S. Verdini; C. M. Deber; E. R. Blout

Publisher: Wiley (John Wiley & Sons)
Year: 1978
Tongue: English
Weight: 586 KB
Volume: 17
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.1978.360171008

No coin nor oath required. For personal study only.

✦ Synopsis

Several cyclic homopeptides containing ~-azetidine-2-carhoxylic acid (Aze)-an imino acid homologous with proline but containing one less methylene group in its cyclic side chain-have been prepared. T h e peptides reported include cyclo(Aze)e, cyclo(Aze):$, and cyclo(Aze),j. T h e synthesis and spectral characterization of these cyclic peptides are described, and the results discussed in terms o f the rigidity and steric constraints attributahle to Azecontaining peptides. CD spectra of these materials in several solvents are reported and compared with those of proline analogs; the similarity between the CD spectra of'cyclo(Aze):% and cyclo(Pro):I is noted.

* This is paper XX of the series "Cyclic Peptides." For the previous paper in this series.

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