Zinc-Induced Conformational Transitions of Acidic Peptides: Characterization by Circular Dichroism and Electrospray Mass Spectrometry

Conformational mapping of a viral fusion

Conformational mapping of a viral fusion peptide in structure-promoting solvents using circular dichroism and electrospray mass spectrometry

✍ Alan J. Waring; Patrick W. Mobley; Larry M. Gordon 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 1 views

The N-terminal domain of human immunodeficiency virus (HIV)-1 glycoprotein 41,000 (FP; residues 1-23; NH 2 -AVGIGALFL-GFLGAAGSTMGARS-CONH 2 ) is involved in the fusion and cytolytic processes underlying viralcell infection. Here, we use circular dichroism (CD) spectroscopy, along with electrospray i