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Synthesis and Characterization of the Antitumor Activities of Analogues of Meridine, a Marine Pyridoacridine Alkaloid

✍ Scribed by Delfourne, Evelyne; Darro, Francis; Bontemps-Subielos, Nataly; Decaestecker, Christine; Bastide, Jean; Frydman, Armand; Kiss, Robert


Book ID
126959447
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
88 KB
Volume
44
Category
Article
ISSN
0022-2623

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Total synthesis of the marine pyridoacri
✍ Laurent Legentil; Jean Bastide; Evelyne Delfourne πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 81 KB

The synthesis of the marine alkaloid sebastianine A and of a regioisomer has been accomplished via hetero-Diels-Alder reaction of indole-4,7-dione or N-tosylindole-4,7-dione with trifluoroacetamidocinnamaldehyde dimethylhydrazone, and subsequent cyclisation in alkaline conditions.