Synthesis and Characterization of Novel Cycloalkanespiro-5-Hydantoin Phosphonic Acids
✍ Scribed by Naydenova, Emilia D.; Todorov, Petar T.; Troev, Kolio D.
- Book ID
- 120340256
- Publisher
- Taylor and Francis Group
- Year
- 2010
- Tongue
- English
- Weight
- 158 KB
- Volume
- 185
- Category
- Article
- ISSN
- 1042-6507
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## Abstract The novel α‐aminophosphonic acids with hydantoin structure have been synthesized reacting 5,5‐dimetylhydantoin with formaldehyde and phosphorus trichloride, or via Kabachnik–Fields reaction. Their structures were proved by means of IR, ^1^__H__, ^13^C{^1^H}, and ^31^P NMR spectroscopy.
## Abstract The __H__‐phosphonate bioconjugates of bile acids, conjugated with various alcohols and nucleosides, were obtained in one pot by a tandem transesterification with diphenyl phosphite (DPP). The synthesis of cholic acid derived phosphoramide from the corresponding __H__‐phosphonate was al