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Novel bile acid derived H-phosphonate conjugates: Synthesis and spectroscopic characterization

✍ Scribed by Yan Li; Weijun Chu; Yong Ju

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
212 KB
Volume
19
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

The H‐phosphonate bioconjugates of bile acids, conjugated with various alcohols and nucleosides, were obtained in one pot by a tandem transesterification with diphenyl phosphite (DPP). The synthesis of cholic acid derived phosphoramide from the corresponding H‐phosphonate was also demonstrated. The structures of these novel conjugates were confirmed on the basis of IR,^31^P NMR, ^1^H NMR, and mass spectra. The synthesized bile acid conjugates were mixtures of diastereoisomers due to the chirality of the phosphorus. Β© 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:402–407, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20447

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