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Synthesis and characterization of improved chloride-sensitive fluorescent indicators for biological applications

โœ Scribed by A.S. Verkman; M.C. Sellers; A.C. Chao; T. Leung; R. Ketcham

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
767 KB
Volume
178
Category
Article
ISSN
0003-2697

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โœฆ Synopsis

The development of Cl-sensitive fluorescent indicators provides a direct approach for measurement of intracellular Cl activity and for analysis of Cl transport mechanisms in biological membranes. The important characteristics of a Cl indicator are high Cl sensitivity and selectivity, rapid response to changes in [Cl], good loading and trapping in cells, low biological toxicity,

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