✍ Scribed by Timo Rager; C. Grant Willson
No coin nor oath required. For personal study only.
The synthesis and detailed NMR analysis of diastereoisomerically pure samples of 4-methyltetracyclo[6.2.1.1 3,6 .0 2,7 ]dodec-9-ene-4-carboxylic acid (2), tetracyclo[6.2.1.1 3,6 .0 2,7 ]dodec-9-ene-4-carboxylic acid ( ) and their tert-butyl esters are reported. Mixtures containing two isomers of the methyl esters of these compounds were obtained by a twofold, sequential Diels-Alder reaction between cyclopentadiene, and methyl methacrylate or methyl acrylate, respectively. Pure diastereoisomers of the acids were prepared by selective hydrolysis of their methyl esters.
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A series of novel 7- (3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3carboxylic acid derivatives was designed, synthesized and characterized by 1 H-NMR, MS and HRMS. These fluoroquinolones were evaluated for their in-vitro antibacterial activity against representat